The Schwann cell at the neuromuscular junction |
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| Affiliation: | 1. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel;2. Wolfson Centre for Applied Structural Biology, The Hebrew University of Jerusalem, Israel;3. Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel;4. Department of Biomedical Engineering and Health Solutions, Royal Technical Institute (KTH), Stockholm, Sweden;5. Department of Nutrition and Biosciences, Karolinska Institute, Huddinge, Sweden;6. Biosciences, University of Exeter, England, UK;1. Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA;2. Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA |
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| Abstract: | Synapses obtained in vitro in a system of co-culture of muscle cells and neurons are of embryonic type. We prepared a monoclonal antibody (6.17) which recognizes a molecule synthesized by Schwann cells and used it to show that the main characteristics of maturity (decrase in number of synapses, appearance of junctional folds, and suppression of butyrylcholinesterase expression) are under the control of Schwann cells. In addition, Schwann cells have the capacity to aggregate the acetylcholine receptors in myotube cultures. |
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