Acute effect of beta amyloid on synchronized spontaneous Ca2+ oscillations in cultured hippocampal networks |
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Authors: | Rui Yanfang Li Ruxin Liu Yifu Zhu Shaoqing Yu Xinzhu Sheng Zhonghua Xie Zuoping |
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Institution: | Department of Biological Science and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China. |
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Abstract: | The effects of beta amyloid (Abeta) on cytoplasmic Ca(2+) (Ca(2+)](c)) have been studied extensively, but the current literature on this aspect is confusing. We reported that 20 microM Abeta(25-35) significantly inhibited the synchronized spontaneous cytoplasmic Ca(2+) transients immediately after application, whereas it had little effect on the baseline Ca(2+)](c) concentration in neurons. Abeta(1-42) had a similar effect on the Ca(2+) transients as Abeta(25-35), while it increased baseline Ca(2+)](c) concentration gradually. However, Abeta(1-40) had little effect on either Ca(2+) transients or baseline Ca(2+)](c). Such differential effects of Abeta on Ca(2+) signals might explain, at least partially, the confusing observations from the previous studies and provide important therapeutic implications for preventing or reversing early neuron damage in Alzheimer's disease. |
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Keywords: | β Amyloid Ca2+ imaging Ca2+ oscillation Ca2+ transient |
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