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Cycle changing the medium results in increased nisin productivity per cell in <Emphasis Type="Italic">Lactococcus lactis</Emphasis> |
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| Authors: | Ömer Simsek Per E J Saris |
| Institution: | (1) Department of Applied Chemistry and Microbiology, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland;(2) Present address: Institute of Biotechnology, University of Ankara, Besevler, Ankara, 06100, Turkey |
| Abstract: | High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation. |
| Keywords: | Cycle changing medium Feedback inhibition Lactococcus lactis Nisin production |
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