The Prognostic Role of mTOR and P-mTOR for Survival in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis |
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| Authors: | Lei Li Dan Liu Zhi-Xin Qiu Shuang Zhao Li Zhang Wei-Min Li |
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| Affiliation: | 1Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China;2Lab of Pathology, Department of Pathology, West China Hospital, Sichuan University, Chengdu, P.R. China;University de Minho, PORTUGAL |
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| Abstract: | ObjectivesThe mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) are potential prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). However, the association between mTOR/p-mTOR expression and NSCLC patients’ prognosis remains controversial. Thus, a meta-analysis of existing studies evaluating the prognostic role of mTOR/p-mTOR expression for NSCLC was conducted.ResultsTen eligible studies were included in this meta-analysis, with 4 about m-TOR and 7 about p-mTOR. For mTOR, the pooled HR of overall survival (OS) was 1.00 (95%CI 0.5 to 1.99) by univariate analysis and 1.22 (95%CI 0.53 to 2.82) by multivariate analysis. For p-mTOR, the pooled HR was 1.39 (95%CI 0.97 to 1.98) by univariate analysis and 1.42 (95%CI 0.56 to 3.60) by multivariate analysis.ConclusionThe results indicated that no statistically significant association was found between mTOR/p-mTOR expression and NSCLC patients’ prognosis. |
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