Event-related Potential Study of the Effects of Emotional Facial Expressions on Task Performance in Euthymic Bipolar Patients |
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Authors: | Estate M Sokhadze Allan Tasman Rebecca Tamas Rif S El-Mallakh |
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Institution: | (1) Cognitive Neuroscience Laboratory, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 401 East Chestnut Street, Suite 610, Louisville, KY 40202, USA;(2) Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 401 East Chestnut Street, Suite 610, Louisville, KY 40202, USA |
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Abstract: | There appears to be a significant disconnect between symptomatic and functional recovery in bipolar disorder (BD). Some evidence
points to interepisode cognitive dysfunction. We tested the hypothesis that some of this dysfunction was related to emotional
reactivity in euthymic bipolar subjects may effect cognitive processing. A modification of emotional gender categorization
oddball task was used. The target was gender (probability 25%) of faces with negative, positive, and neutral emotional expression.
The experiment had 720 trials (3 blocks × 240 trials each). Each stimulus was presented for 150 ms, and the EEG/ERP responses
were recorded for 1,000 ms. The inter-trial interval was varied in 1,100–1,500 ms range to avoid expectancy effects. Task
took about 35 min to complete. There were 9 BD and 9 control subjects matched for age and gender. Reaction time (RT) was globally
slower in BD subjects. The centro-parietal amplitudes at N170 and N200, and P200 and P300 were generally smaller in the BD
group compared to controls. Latency was shorter to neutral and negative targets in BD. Frontal P200 amplitude was higher to
emotional negative facial non-targets in BD subjects. The frontal N200 in response to positive facial emotion was less negative
in BD subjects. The frontal P300 of BD subjects was lower to emotionally neutral targets. ERP responses to facial emotion
in BD subjects varied significantly from normal controls. These variations are consistent with the common depressive symptomology
seen in long term studies of bipolar subjects. |
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Keywords: | |
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