KIR/HLA pleiotropism: protection against both HIV and opportunistic infections |
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| Authors: | Qi Ying Martin Maureen P Gao Xiaojiang Jacobson Lisa Goedert James J Buchbinder Susan Kirk Gregory D O'Brien Stephen J Trowsdale John Carrington Mary |
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| Affiliation: | Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA. |
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| Abstract: | The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS. |
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