Abrogation of resistance to the reinduction of experimental allergic encephalomyelitis by pertussigen |
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Authors: | F J Waxman R K Bergman J J Munoz |
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Institution: | U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Persistent Viral Diseases, and Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, Hamilton, Montana 59840 U.S.A. |
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Abstract: | Experimental allergic encephalomyelitis is an autoimmune disease initiated by an injection of myelin basic protein in complete Freund's adjuvant. Lewis rats which have recovered from the initial episode of hindquarter paralysis are resistant for at least 6 months to disease reinduction by basic protein-complete Freund's adjuvant, although specific antigen-reactive cells are detectable in convalescent rats. Resistance cannot be attributed to the activity of the adjuvant alone. In contrast, clinical disease could be reinduced by a secondary challenge with spinal cord homogenate and pertussigen (“lymphocytosis promoting factor” of Bordetella pertussis). Disease could also be reinduced by a simultaneous secondary challenge with basic protein-complete Freund's adjuvant along with pertussigen. Vascular permeability increases in the spinal cord paralleled disease induction or reinduction. No definite conclusions can be drawn concerning the mechanism by which pertussigen promotes disease reinduction in convalescent rats. |
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Keywords: | To whom correspondence should be addressed Present address: Department of Medicine Renal Disease Division Ohio State University N-210 Means Hall 1655 Upham Dr Columbus Ohio 43210 |
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