Secondary structure of the promastigote surface protease of Leishmania |
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Authors: | F J?hnig R Etges |
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Institution: | Max-Planck-Institut für Biologie, Tübingen, FRG. |
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Abstract: | By Raman spectroscopic analysis we have determined the secondary structure of the promastigote surface protease, named PSP or gp63, of Leishmania major. It consist of nearly 50% antiparallel beta-strand, and less than 20% alpha-helix. These results are contrasted with the predominantly alpha-helical VSGs of the African trypanosomes and the alpha-helical metalloprotease thermolysin. The PSP of Leishmania thus represents a novel kind of membrane-anchored protease. |
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