Expression of fucose residues in entero-endocrine cells |
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Authors: | A Gebert Y Cetin |
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Institution: | (1) Abteilung Anatomie 2, Medizinische Hochschule Hannover, D-30623 Hannover, Germany Tel. +49 511 532 2904; fax. +49 511 532 2948, DE;(2) Institute of Anatomy and Cell Biology, University of Marburg, Marburg, Germany, DE |
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Abstract: | The binding of the fucose-specific lectin, Ulex europaeus agglutinin (UEA-I), to entero-endocrine cells was studied in the ileum and caecum of humans, rabbits, rats, and mice. In
all species investigated, numerous cells scattered in the crypt and villus epithelia intensely bound the UEA-I lectin. These
cells proved to be argyrophilic and were identified as enterochromaffin cells and peptide tyrosine tyrosine cells by immunohistochemistry.
They mostly reached the gut lumen (”open type”) by slender cellular processes. At the ultrastructural level, fucose binding
sites were located in the matrix of the electron-dense secretory granules of these cells and in the glycocalyx covering their
apical membrane. The results show that in various mammalian species entero-endocrine cells of defined types express fucose-bearing
glycoconjugates. The presence of fucose residues in the apical membrane of entero-endocrine cells indicates that this membrane
domain has a specialized composition of intramembranous glycoconjugates which could be involved in receptive and/or secretory
functions.
Accepted: 12 June 1997 |
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