Persistent Chlamydiae and chronic arthritis |
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Authors: | Thomas A Einhorn |
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Institution: | (1) Professor and Chairman, Department of Orthopedic Surgery, Boston University Medical Center, Boston, Massachusetts, USA; |
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Abstract: | Prostaglandins are important mediators of bone repair, and cyclooxygenases are required for prostaglandin production. Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair fracture healing but that this is due to the inhibition of COX-2 and not COX-1. Although these data raise concerns about the use of COX-2-specific inhibitors as anti-inflammatory or anti-analgesic drugs in patients undergoing bone repair, clinical reports have been inconclusive. Because animal data suggest that the effects of COX-2 inhibitors are both dose-dependent and reversible, in the absence of scientifically sound clinical evidence it is suggested that physicians consider short-term administration or other drugs in the management of these patients. |
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Keywords: | Chlamydia pneumoniae Chlamydia trachomatis inflammation molecular genetics pathogenesis reactive arthritis |
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