Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists |
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| Authors: | Sato Nagaaki Shibata Takunobu Jitsuoka Makoto Ohno Toshiyuki Takahashi Toshiyuki Hirohashi Tomoko Kanno Tetsuya Iwaasa Hisashi Kanatani Akio Fukami Takehiro |
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| Institution: | Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan. satoung@banyu.co.jp |
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| Abstract: | A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described. |
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