3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents |
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| Authors: | Kashiwada Y Chiyo J Ikeshiro Y Nagao T Okabe H Cosentino L M Fowke K Lee K H |
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| Institution: | Niigata College of Pharmacy, Japan. kasiwada@niigata-pharm.ac.jp |
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| Abstract: | Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400. |
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