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Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin
Authors:N G Morgan  C C Shipp  J H Exton
Institution:Department of Biochemistry, Cornell University Medical College, New York, NY 10021, USA
Abstract:Vasopressin elicited a dose-dependent inhibition of glucagon-induced cAMP accumulation in isolated hepatocytes. This response was not diminished by incubation of cells with the calmodulin antagonists trifluoperazine or chlorpromazine and was only slightly reduced in Ca2+-depleted hepatocytes. Half-maximal inhibition of cAMP accumulation occurred at 8 X 10(-11) M vasopressin, a dose which does not increase cytosolic Ca2+ in hepatocytes. Direct activation of adenylate cyclase by forskolin was significantly inhibited by vasopressin in Ca2+-depleted cells. It is concluded that inhibition of hormone-induced cAMP accumulation by vasopressin in liver is not dependent on cellular Ca2+ mobilisation but may involve direct inhibition of adenylate cyclase.
Keywords:Thyroliberin  Carboxy terminal amide  Amidation  Pituitary
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