Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: a new class of anti-HIV agents |
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| Authors: | Hagihara M Kashiwase H Katsube T Kimura T Komai T Momota K Ohmine T Nishigaki T Kimura S Shimada K |
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| Affiliation: | Pharmaceutical Research Department, Ube Laboratory, Ube Industries, Ltd., Ube City, Yamaguchi, Japan. |
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| Abstract: | Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent anti-HIV activity: IC50=0.06 microM in chronically infected cells. |
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