Midkine as a novel target for antibody therapy in osteosarcoma |
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Authors: | Maehara Hiroki Kaname Tadashi Yanagi Kumiko Hanzawa Hiroaki Owan Ichiro Kinjou Takao Kadomatsu Kenji Ikematsu Shinya Iwamasa Teruo Kanaya Fuminori Naritomi Kenji |
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Affiliation: | Department of Orthopedics, University of the Ryukyus Faculty of Medicine, 207 Uehara, Nishihara, Okinawa 903-0215, Japan. |
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Abstract: | Osteosarcoma is a malignant tumor with poor prognosis, and lack of accurate prognostic factors is one of the reasons that make this tumor difficult to cure. The heparin-binding growth factor, midkine is involved in generation and progression of many types of tumors. However, the relationship between midkine and osteosarcoma has been unclear. We show here that midkine is overexpressed in osteosarcoma and the level of midkine expression is correlated with prognosis (P<0.05; log-rank test). Treatment with functional antibodies against midkine suppresses growth of osteosarcoma cell lines, 9N2, 3N1, Saos-2, and NOS-1, to 25-65% of untreated controls. Our results suggest that midkine is useful as a prognostic marker, and is a candidate therapeutic target for osetosarcomas. |
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Keywords: | MK, midkine anti-MK antibody, goat polyclonal anti-midkine antibody MRI, magnetic resonance imaging ALP, alkaline phosphatase PTN, pleiotrophin |
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