Activity-Dependent Dendritic Release of BDNF and Biological Consequences |
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Authors: | Nicola Kuczewski Christophe Porcher Volkmar Lessmann Igor Medina Jean-Luc Gaiarsa |
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Affiliation: | (1) INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901), Université de La Méditerranée, Parc scientifique de Luminy, BP 13, 13273 Marseille Cedex 09, France;(2) Institute of Physiology, Otto-von-Guericke-University, Magdeburg, Germany |
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Abstract: | Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level. |
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Keywords: | BDNF Neurotrophin Development Action potential Activity-dependent maturation |
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