c-Ha-ras-1 alleles in bladder cancer,Wilms' tumour and malignant melanoma |
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| Authors: | N. K. Hayward R. Keegan D. J. Nancarrow M. H. Little P. J. Smith R. A. Gardiner G. J. Seymour C. Kidson M. F. Lavin |
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| Affiliation: | (1) Queensland Institute of Medical Research, Bramston Terrace, Herston, 4006 Brisbane, Australia;(2) Biochemistry Department, University of Queensland, St. Lucia, 4067 Brisbane, Australia;(3) Department of Surgery, University of Queensland, Royal Brisbane Hospital, Herston, 4006 Brisbane, Australia;(4) Department of Social and Preventive Dentistry, University of Queensland Dental School, Turbot Street, 4000 Brisbane, Australia |
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| Abstract: | Summary Polymorphism of the human c-Ha-ras-1 gene has been analysed in DNA from 168 individuals using the enzymes MspI and HpaII. In all, 35 bladder cancer patients, 28 melanoma patients, 22 Wilms' tumour patients, 24 first-degree relatives of Wilms' tumour or melanoma patients and 59 unaffected controls were studied. A total of 13 different fragment sizes was detected, 4  common and 9 unusual. Of the latter, 4 were observed only in cancer patients or their first-degree relatives. The frequency of unusual alleles was significantly greater in bladder cancer patients and in the combined tumour group than in controls, thus providing support for the association of unique Ha-ras alleles and cancer. Some unaffected relatives of patients carried unusual alleles, and thus there is no absolute relationship between Ha-ras genotype and disease. |
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