Vacuum ultraviolet circular dichroism spectrum of beta-turn in solution. |
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Authors: | S K Brahmachari V S Ananthanarayanan S Brahms J Brahms R S Rapaka R S Bhatnagar |
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Affiliation: | 4. School of Dentistry, University of California, San Francisco, 94143, U.S.A. |
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Abstract: | The vacuum ultraviolet circular dichroism spectrum of an isolated 4 → 1 hydrogen bonded β-turn is reported. The observed spectrum of N-acetyl-Pro-Gly-Leu-OH at ? 40°C in trifluoroethanol is in good agreement with the theoretically calculated CD spectrum of the β-turn conformation. This spectrum, particularly the presence of a strong negative band around 180 nm and a large ratio , can be taken as a characteristic feature of the isolated β-turn conformation. These CD spectral features can thus be used to distinguish the β-turn conformation from the β-structure in solution. |
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Keywords: | To whom to address correspondence. |
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