The stimulus-secretion coupling of glucose-induced insulin release. XLIII. Na-Ca countertransport mediated by pancreatic islet native ionophores |
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Authors: | K Anjaneyulu R Anjaneyulu W J Malaisse |
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Institution: | Laboratory of Experimental Medicine, Brussels University Belgium |
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Abstract: | Native ionophores extracted from isolated pancreatic islets were able to transport Ca2+ from one aqueous medium into another across an organic immiscible phase. In the presence of a K+, Na+, Li+, or H+ gradient, Ca2+ was transported against its own concentration gradient from the medium of low monovalent-cation concentration to the opposite medium. The transport of Ca2+ was abolished by the organic calcium-antagonist suloctidil. These findings provide a model for the process of Na-Ca countertransport in islet cells and its inhibition in response to the conversion of nutrient secretagogues to their acidic metabolites. |
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Keywords: | Address reprint requests to: Laboratory of Experimental Medicine 115 Boulevard de Waterloo Brussels B-1000 Belgium |
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