Groove selectivity in the interaction of 9-aminoacridine-4-carboxamide antitumor agents with DNA |
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| Authors: | K X Chen N Gresh B Pullman |
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| Affiliation: | Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, Paris, France. |
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| Abstract: | Theoretical quantitative evaluation of the intercalative binding to DNA of the new antitumor drug 9-aminoacridine-4-carboxamide indicates that, in contradiction with a recently proposed model, the compound should show specificity for interaction with the major (and not minor) groove of GC sequences. |
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