Dynamics of success and failure in phage and antibiotic therapy in experimental infections |
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| Authors: | J J Bull Bruce R Levin Terry DeRouin Nina Walker Craig A Bloch |
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| Institution: | (1) Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712-1023, USA;(2) Department of Biology, Emory University, Atlanta, GA 30322, USA;(3) Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48104, USA |
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| Abstract: | Background In 1982 Smith and Huggins showed that bacteriophages could be at least as effective as antibiotics in preventing mortality
from experimental infections with a capsulated E. coli (K1) in mice. Phages that required the K1 capsule for infection were
more effective than phages that did not require this capsule, but the efficacies of phages and antibiotics in preventing mortality
both declined with time between infection and treatment, becoming virtually ineffective within 16 hours. |
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