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Effect of hypocholesterolemic agents of plant origin on catecholamine biosynthesis in normal and cholesterol fed rabbits
Authors:Madhulika Srivastava  Swarn Nityanand  Narinder K. Kapoor
Affiliation:(1) Division of Biophysics, Central Drug Research Institute, 226 001 Lucknow, India
Abstract:The effect of lipid lowering agents of plant origin garlic oil and guggulipid on the levels of catecholamine and dopamine Β-hydroxylase activity of normal and cholesterol fed rabbit tissues has been studied. The catecholamine levels and enzyme activity were found to be decreased in cholesterol (500 mg/kg body wt) fed animals. The feeding of garlic oil (5 mg/kg body wt) and guggulipid (100 mg/kg body wt) an exudate ofCommiphora mukul, to normal rabbits caused significant increase in the dopamine-Β-hydroxylase activity and catecholamine levels, while the feed helped the hypercholesterolemic rabbits to recover the decrease in catecholamine biosynthesis C.D.R.I. Communication No. 3435.
Keywords:Catecholamine biosynthesis  dopamine Β  -hydroxylase  cholesterol  garlic oil  guggulipid   Commiphora mukul   hypolipidaemic
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