Respiration modulates oscillatory neural network activity at rest |
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| Authors: | Daniel S. Kluger Joachim Gross |
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| Affiliation: | 1. Institute for Biomagnetism and Biosignal Analysis, University of Muenster, Muenster, Germany;2. Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany;3. Centre for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom; New York University, UNITED STATES |
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| Abstract: | Despite recent advances in understanding how respiration affects neural signalling to influence perception, cognition, and behaviour, it is yet unclear to what extent breathing modulates brain oscillations at rest. We acquired respiration and resting state magnetoencephalography (MEG) data from human participants to investigate if, where, and how respiration cyclically modulates oscillatory amplitudes (2 to 150 Hz). Using measures of phase–amplitude coupling, we show respiration-modulated brain oscillations (RMBOs) across all major frequency bands. Sources of these modulations spanned a widespread network of cortical and subcortical brain areas with distinct spectrotemporal modulation profiles. Globally, delta and gamma band modulations varied with distance to the head centre, with stronger modulations at distal (versus central) cortical sites. Overall, we provide the first comprehensive mapping of RMBOs across the entire brain, highlighting respiration–brain coupling as a fundamental mechanism to shape neural processing within canonical resting state and respiratory control networks (RCNs).Despite recent advances, it remains unclear to what extent breathing modulates brain oscillations at rest. This magnetoencephalography study in human participants identifies a widespread brain network of neural oscillations that are coupled to the respiratory rhythm. |
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