Genetic and phenotypic diversity in <Emphasis Type="Italic">Burkholderia</Emphasis>: contributions by prophage and phage-like elements |
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| Authors: | Catherine M Ronning Liliana Losada Lauren Brinkac Jason Inman Ricky L Ulrich Mark Schell William C Nierman David DeShazer |
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| Institution: | (1) J. Craig Venter Institute, 9704 Medical Center Drive, 20850 Rockville, MD, USA;(2) U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, 21702 Fort Detrick, MD, USA;(3) Department of Microbiology, University of Georgia, 30602 Athens, GA, USA;(4) U.S. Department of Energy, Office of Biological and Environmental Research, SC-23.2/Germantown Building, 1000 Independence Avenue SW, 20585-1290 Washington, DC, USA |
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| Abstract: | Background
Burkholderia species exhibit enormous phenotypic diversity, ranging from the nonpathogenic, soil- and water-inhabiting Burkholderia thailandensis to the virulent, host-adapted mammalian pathogen B. mallei. Genomic diversity is evident within Burkholderia species as well. Individual isolates of Burkholderia pseudomallei and B. thailandensis, for example, carry a variety of strain-specific genomic islands (GIs), including putative pathogenicity and metabolic islands,
prophage-like islands, and prophages. These GIs may provide some strains with a competitive advantage in the environment and/or
in the host relative to other strains. |
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