Delayed aggregation of proteoglycans in adult human articular cartilage |
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| Authors: | Michael T Bayliss George D Ridgway S Yousuf Ali |
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| Institution: | (1) Division of Biochemistry, Kennedy Institute of Rheumatology, W6 7DW London, UK;(2) Experimental Pathology Unit, Institute of Orthopaedics, Royal National Orthopaedic Hospital, Brockley Hill, HA7 4LP Stanmore, Middlesex, UK |
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| Abstract: | The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of proteoglycans into the extraceHular matrix may be controlled. |
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