Oxidative Damage to DNA and Deoxyribose by β-Lactam Antibiotics in the Presence of Iron and Copper Salts |
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Authors: | Gregory J Quinlan John M C Gutteridge |
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Institution: |
a Division of Chemistry, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts |
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Abstract: | β-lactam antibiotics in the presence of certain metal ions damage deoxyribose and DNA with the release of thiobarbituric acid-reactive material. This damage can be substantially prevented by catalase, metal chelators and some scavengers of the hydroxyl radical. Ferric salts in the presence of certain β-lactam antibiotics were effective in degrading deoxyribose but they did not appear to damage DNA. In contrast copper salts and p-lactam antibiotics were extremely effective in damaging both DNA and deoxyribose. |
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Keywords: | β-lactam antibiotics DNA Deoxyribose oxidation |
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