In vivo development of the lethal yellow (Ay/Ay) mouse embryo at 105 hours post coitum |
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| Authors: | Gerald R Cizadlo Nels H Granholm |
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| Institution: | (1) Department of Biology, College of St. Scholastica, 1200 Kenwood Avenue, Duluth, Minnesota, USA;(2) Electron Microscope Laboratory, Veterinary Science 113, South Dakota State University, 57006 Brookings, S. Dakota, USA |
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| Abstract: | When histologically examined in utero at 105 hours post coitum embryos from A
y
/a × A
y
/a matings contained a mean (± SE) of 122.7 ± 6.5 nuclei per embryo; of these, 30.2 ± 2.4 nuclei were in the inner cell mass (ICM) and 92.5 ± 4.8 nuclei were within trophoblast cells. Embryos from  A
y
/a ×  a/a matings contained a mean of 141.4 ± 10.6 nuclei per embryo of which 41.7 ± 4.5 nuclei were within the ICM and 99.7 ± 6.9 nuclei were trophoblastic. ICM cell numbers were significantly different between genotypes (P < 0.05) suggesting that homozygous A
y
allele expression selectively interferes with ICM versus trophoblast cell differentiation during preimplantation development. |
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