首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Association of Adiposity Indices with Platelet Distribution Width and Mean Platelet Volume in Chinese Adults
Authors:Jian Hou  Chuanyao Liu  Ping Yao  Weihong Chen  Meian He  Youjie Wang  Yuan Liang  Xiaoping Miao  Sheng Wei  Tian Xu  Weimin Fang  Jiang Zhu  Xiulou Li  Frank B Hu  Tangchun Wu  Handong Yang  Jing Yuan
Abstract:Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV) and platelet distribution width (PDW) are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 females) from the Dongfeng-Tongji Cohort Study (DFTJ-Cohort Study, n=27009) were included in this study, except for 9682 individuals with missing data on demographical, lifestyle, physical indicators and diseases relative to PDW and MPV. Associations between adiposity indices including waist circumstance (WC), waist-to-height ratio (WHtR), body mass index (BMI), and MPV or PDW in the participants were analyzed using multiple logistic regressions. There were significantly negative associations between abnormal PDW and WC or WHtR for both sexes (p trend<0.001 for all), as well as abnormal MPV and WC or WHtR among female participants (p trend<0.05 for all). In the highest BMI groups, only females with low MPV or PDW were at greater risk for having low MPV (OR=1.33, 95% CI=1.10, 1.62 p trend<0.001) or PDW (OR=1.34, 95% CI=1.14, 1.58, p trend<0.001) than those who had low MPV or PDW in the corresponding lowest BMI group. The change of PDW seems more sensitive than MPV to oxidative stress and hypoxia. Associations between reduced PDW and MPV values and WC, WHtR and BMI values in Chinese female adults may help us to further investigate early changes in human body.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号