Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes |
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Authors: | Sasaki Makoto Tsubone Koichi Shoji Muneo Oikawa Masato Shimamoto Keiko Sakai Ryuichi |
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Affiliation: | Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Sendai 981-8555, Japan. masasaki@bios.tohoku.ac.jp |
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Abstract: | To enable studies to elucidate the detailed biological function of dysiherbaine and neodysiherbaine A, potent and subunit-selective agonists for ionotropic glutamate receptors, the derivative with a hydroxymethyl substituent at the C10 position has been developed. Preliminary biological evaluation of the analogue showed that a C10 hydroxymethyl substituent produced significant alterations in binding affinities for the ionotropic glutamate receptor subtypes. |
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