In vitro susceptibility ofTrichophyton rubrum isolates to griseofulvin and tioconazole. Induction and isolation of a resistant mutant to both antimycotic drugs |
| |
| Authors: | Ana Lucia Fachin Claudia Maria Leite Maffei Nilce Maria Martinez-Rossi |
| |
| Institution: | (1) Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, USP, 14049-900 Ribeirao Preto, Sao Paulo, Brazil;(2) Departamento de Parasitologia Microbiologia e Imunologia, Faculdade de Medicina de Ribeirao Preto, USP, 14049-900 Ribeirao Preto, Sao Paulo, Brazil |
| |
| Abstract: | The in vitro susceptibility of three clinicalTrichophyton rubrum isolates to griseofulvin and tioconazole, determined by the minimal inhibitory concentration (MIC), was 2 and 0.5 to 1.0 g/ml, respectively. One mutant (gril) obtained after mutagenic treatment of one of these isolates was selected and showed simultaneous resistance to griseofulvin (MIC > 2000g/ml) and tioconazole (MIC=1.0g/ml). The clinical importance and the possibility of a multidrug resistance (MDR)-type mechanism being involved in this event is discussed. |
| |
| Keywords: | dermatophyte drug resistance fungi griseofulvin resistance tioconazole resistance Trichophyton rubrum |
| 本文献已被 SpringerLink 等数据库收录！ |
|
