Apo and inhibitor complex structures of BACE (beta-secretase) |
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| Authors: | Patel Sahil Vuillard Laurent Cleasby Anne Murray Christopher W Yon Jeff |
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| Affiliation: | Astex Technology, 436 Cambridge Science Park, Milton Road, CB4 0QA, UK. |
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| Abstract: | Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design. |
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| Keywords: | BACE crystallography drug discovery Alzheimer's disease |
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