Detection of multiple cytokines in the urine of patients with focal necrotising glomerulonephritis may predict short and long term outcome of renal function |
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Authors: | Stangou Maria Papagianni Aikaterini Bantis Christos Liakou Helen Pliakos Kostas Giamalis Panagiotis Gionanlis Lazaros Pantzaki Afroditi Efstratiadis Georgios Memmos Dimitrios |
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Affiliation: | a Department of Nephrology, Aristotle University of Thessaloniki, Hippokration General Hospital, 49 Konstantinoupoleos Str., 54642 Thessaloniki, Greece b Department of Pathology, Hippokration General Hospital, Thessaloniki, Greece |
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Abstract: | BackgroundDetection of urinary cytokines in pauci-immune focal segmental necrotizing glomerulonephritis (FSNGN) may provide valuable information about disease pathogenesis and prognosis.MethodsEpidermal growth factor (EGF), transforming growth factor (TGF-β1) and vascular endothelial growth factor (VEGF) were measured by ELISA, and Interleukins, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP1β) by a multiplex cytokine assay, in 38 patients with FSNGN. Their levels were correlated with severity of histological findings and renal function outcome in short and long term.ResultsThe percentage of crescents in renal biopsy had positive correlation with TGF-β1 (p = 0.004) and IL-15 urinary excretion (p = 0.01), and negative correlation with EGF (p = 0.01). Increased urinary excretion of IL-6, IL-15, VEGF and MIP-1β was associated with poor renal function outcome, but increased levels of EGF, IL-2 and IL-9 predicted a favourable prognosis. In multiple regression analysis IL-6 and VEGF urinary levels were independent predictors of no-response at the acute phase (p = 0.001 and p < 0.0001, respectively), while, IL-6 was the only factor (p = 0.03) predicted worse outcome at the end of follow-up (39.4 ± 45 months).ConclusionIncreased urinary excretion of IL-6, IL-15, VEGF, TGF-β1, MCP-1 and MIP-1β and reduced EGF, IL-2, IL-9 may be associated with histological damage and influence response to treatment in pauci-immune FSNGN. |
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Keywords: | Growth factors Interleukins Necrotising glomerulonephritis outcome Urine |
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