High plasma CXCL10 levels are associated with HCV-genotype 1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients |
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Authors: | Berenguer Juan Fernandez-Rodríguez Amanda Jimenez-Sousa Maria Angeles Cosín Jaime Zarate Paola Micheloud Dariela López Juan Carlos Miralles Pilar Catalán Pilar Resino Salvador |
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Institution: | a Infectious Diseases-HIV Unit, Hospital General Universitario “Gregorio Marañón”, Madrid, Spain b Laboratory of Molecular Epidemiology of Infectious Diseases, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain c Family and Community Medicine Department, Hospital General Universitario “Gregorio Marañón”, Madrid, Spain d Internal Medicine Department, Hospital General Universitario “Gregorio Marañón”, Madrid, Spain e Microbiology Department, Hospital General Universitario “Gregorio Marañón”, Madrid, Spain |
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Abstract: | BackgroundCXCL10 may contribute to the host immune response against the hepatitis C virus (HCV), liver disease progression, and response to HCV antiviral therapy. The aim of our study was to analyze the relationship among virological, immunological, and clinical characteristics with plasma CXCL10 levels in human immunodeficiency virus (HIV)/HCV-coinfected patients.MethodsWe carried out a cross-sectional study on 144 patients. CXCL10 and insulin were measured using an immunoassay kit. The degree of insulin resistance was estimated for each patient using the homeostatic model assessment (HOMA) method. Insulin resistance was defined as a HOMA index higher than or equal to 3.8. Aspartate aminotransferase (AST) to platelet ratio (APRI), FIB-4, Forns index, HGM1, and HGM2 were calculated.ResultsThe variables associated with log10 CXCL10 levels by univariate analysis were age (b = 0.013; p = 0.023), prior AIDS-defining condition (b = 0.127; p = 0.045), detectable plasma HIV viral load (b = 0.092; p = 0.006), log10 HOMA (b = 0.216; p = 0.002), HCV-genotype 1 (b = 0.114; p = 0.071), and liver fibrosis assessed by all non-invasive indexes (log10 APRI (b = 0.296; p = 0.001), log10 FIB-4 (b = 0.436; p < 0.001), log10 Forns index (b = 0.591; p < 0.001), log10 HGM1 (b = 0.351; p = 0.021), and log10 HGM2 (b = 0.215; p = 0.018)). However, in multivariate analysis, CXCL10 levels were only associated with HOMA, detectable plasma HIV viral load, HCV-genotype 1 and FIB-4 (R-square = 0.235; p < 0.001).ConclusionPlasma CXCL10 levels were influenced by several characteristics of patients related to HIV and HCV infections, insulin resistance, and liver fibrosis, indicating that CXCL10 may play an important role in the pathogenesis of both HCV and HIV infections. |
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Keywords: | Chemokine HOMA AIDS Chronic hepatitis C Inflammation |
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