Aspergillus in the Intensive Care Unit |
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Authors: | Markus Ruhnke Peter Kujath Dirk Vogelaers |
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Institution: | 1. Medizinische Klinik und Poliklinik, m. S. Onkologie & H?matologie, Charit?? Universit?tsmedizin Berlin, Campus Charit?? Mitte, Charit??platz 1, 10117, Berlin, Germany 2. Klinik f??r Chirurgie, Universit?tsklinikum Schleswig-Holstein, Campus L??beck, L??beck, Germany 3. Department of Infectious Diseases, Ghent University Hospital, Ghent, Belgium
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Abstract: | Invasive aspergillosis (IA), the most life-threatening form of aspergillosis, has become a major opportunistic fungal disease
in immunocompromised patients. In high-risk patients with hematologic malignancies, IA appears to decline with the use of
mold-active antifungal prophylaxis, but the situation is less clear in other patient groups at risk for IA, and precise epidemiologic
data from patients treated in intensive care units (ICUs) are lacking. Most Aspergillus culture isolates from nonsterile body sites do not represent disease, but isolation of Aspergillus in critically ill patients is a marker of poor prognosis and is associated with high mortality regardless of invasion or
colonization. This review presents current information on epidemiology, risk factors, and diagnosis, and discusses treatment
options for patients with IA in the ICU. |
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Keywords: | |
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