Synthesis and antiviral activity against tobacco mosaic virus and 3D-QSAR of alpha-substituted-1,2,3-thiadiazoleacetamides |
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Authors: | Zhao Wei-Guang Wang Jian-Guo Li Zheng-Ming Yang Zhao |
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Institution: | National Pesticide Engineering Research Center (Tianjin), State Key Laboratory of Elmento-Organic Chemistry, Nankai University, Tianjin 300071, PR China. zwg@nankai.edu.cn |
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Abstract: | A series of alpha-substituted-1,2,3-thiadiazoleacetamides were prepared and tested in vitro against tobacco mosaic virus. The preliminary bioassays indicated that some of the new compounds are good as compared to the commercial pesticide Virus A at 500 mg/L, and the activity was influenced by the nature of the substituents. 3D-QSAR models were established based on the antiviral activity of the compounds. It has also been found that some of the new compounds also exhibit significant anti-HBV activity in human hepatoblastoma-derived liver Hep-G2 cells. |
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