The relationship between the pY+3 amino acid in the phosphopeptide ligands and the specificity for various SH2 domains |
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Authors: | Lee Keun-Hyeung Park See-Hyoung |
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Institution: | Department of Chemistry, Inha University, 253 Younghyong-Dong, Nam-Gu, Inchon-City 402-751, South Korea. leekh@inha.ac.kr |
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Abstract: | After consideration of the tertiary structure of the pY+3 binding pocket in SH2 domains, isoleucine of Ac-pYEEIE was replaced with various unnatural aliphatic amino acids and the binding affinities for Lck, Src, and Fyn SH2 domains were measured. We determined the characteristics of the amino acid at the pY+3 position in the phosphopeptide ligands for the specificity for the SH2 domains. |
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