Automated computed tomographic scoring of lung disease in adults with primary ciliary dyskinesia |
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Authors: | Trieu-Nghi Hoang-Thi Marie-Pierre Revel Pierre-Régis Burgel Laurence Bassinet Isabelle Honoré Thong Hua-Huy Charlotte Martin Bernard Maitre Guillaume Chassagnon |
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Affiliation: | 1.Radiology Department,Groupe Hospitalier Cochin-H?tel Dieu, AP-HP, Université Paris Descartes - Sorbonne Paris Cité,Paris,France;2.Pulmonary Department,Groupe Hospitalier Cochin-H?tel Dieu, AP-HP, Université Paris Descartes - Sorbonne Paris Cité,Paris,France;3.Service de Pneumologie et de Pathologie Professionnelle,DHU A-TVB, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Créteil,Créteil,France;4.Physiology Department,Groupe Hospitalier Cochin-H?tel Dieu, AP-HP, Université Paris Descartes - Sorbonne Paris Cité,Paris,France;5.Center for Visual Computing,CentraleSupelec,Gif-sur-Yvette,France;6.Department Diagnostic Imaging,Vinmec International Hospital – Central Park,Ho Chi Minh City,Vietnam |
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Abstract: | BackgroundThe present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structural abnormalities in patients with Primary Ciliary Dyskinesia (PCD).MethodsAdult (≥18?years) PCD patients who underwent both chest CT and spirometry within a 6-month period were retrospectively included. Commercially available lung segmentation software was used to isolate the lungs from the mediastinum and chest wall and obtain histograms of lung density. CT-density scores were calculated using fixed and adapted thresholds based on various combinations of histogram characteristics, such as mean lung density (MLD), skewness, and standard deviation (SD). Additionally, visual scoring using the Bhalla score was performed by 2 independent radiologists. Correlations between CT scores, forced expiratory volume in 1?s (FEV1) and forced vital capacity (FVC) were evaluated.ResultsSixty-two adult patients with PCD were included. Of all histogram characteristics, those showing good positive or negative correlations to both FEV1 and FVC were SD (R?=???0.63 and???0.67; p?0.001) and Skewness (R?=?0.67 and 0.67; p?0.001). Among all evaluated thresholds, the CT-density score based on MLD?+?1SD provided the best negative correlation with both FEV1 (R?=???0.68; p?0.001) and FVC (R?=???0.71; p?0.001), close to the correlations of the visual score (R?=???0.60; p?0.001 for FEV1 and R?=???0.62; p?0.001, for FVC).ConclusionsAutomated CT scoring of lung structural abnormalities lung in primary ciliary dyskinesia is feasible and may prove useful for evaluation of disease severity in the clinic and in clinical trials. |
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