Antioxidant Properties and UV Absorbance Pattern of Mycosporine‐Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner |
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| Authors: | Daniel Andreguetti Erika M. Stein Claudio M. P. Pereira Ernani Pinto Pio Colepicolo |
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| Affiliation: | 1. Department of Clinical Chemistry, Faculty of Pharmaceutical Sciences, University of S?o Paulo, , 05508‐900 S?o Paulo‐SP, Brazil;2. Center for Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, , 96010‐900 Pelotas‐RS, Brazil;3. Institute of Chemistry, University of S?o Paulo, , 05508‐900 S?o Paulo‐SP, Brazil |
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| Abstract: | In current study, we report efficient and clean procedure for preparing mycosporine‐like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC50 in the DPPH assay. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:305‐312, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21489 |
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| Keywords: | Antioxidant Mycosporine‐like amino acids Green chemistry UV absorbance |
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