Emerging molecular networks in Burkitt's lymphoma |
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| Authors: | Davide Mangani Annalisa Roberti Flavio Rizzolio Antonio Giordano |
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| Institution: | 1. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA;2. Human Health Foundation, Terni and Spoleto (PG), Italy;3. Experimental and Clinical Pharmacology ‐ National Cancer Institute IRCCS Aviano, Italy;4. Department of Human Pathology and Oncology, University of Siena, Siena, Italy |
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| Abstract: | Burkitt's lymphoma (BL), one of the most aggressive tumors affecting humans, characterized by the constitutive activation of the Myc oncogene together with the alteration of many other genetic and epigenetic factors. Among them, the INK4a/ARF locus has been well documented to play a central role in BL. Recently, we have discovered that simultaneous deregulation of both DNA methylation patterns and the ubiquitin‐dependent proteolysis system is required to completely inactive the INK4/ARF locus, opening new possibilities for treating Burkitt's lymphoma. In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease. J. Cell. Biochem. 114: 35–38, 2012. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | BURKITT'S LYMPHOMA PROTEASOME miRNA |
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