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The role of lncRNA OIP5-AS1 in cancer development and progression |
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| Authors: | Zheng Cheng Chu Man Chen Qiuli Chen Cheng Wang Zhi-Wei Chen Xiao |
| Institution: | 1.The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China ;2.Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China ;3.Department of Research and Development, Zhengjiang Zhongwei Medical Research Center, Hangzhou, 310018, Zhejiang, China ;4.The School of Public Health, The University of Queensland, Brisbane, Australia ;5.Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China ; |
| Abstract: | OIP5-AS1, a conserved lncRNA, has been reported to be involved in several biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its oncogenic or antitumor functions via regulation of different miRNAs in various cancer types. In this review, we describe the dysregulation of OIP5-AS1 expression in a variety of human cancers. Moreover, we discuss the multiple functions of OIP5-AS1 in cancer, including in proliferation, apoptosis, autophagy, ferroptosis, cell cycle, migration, metastasis, invasion, epithelial to mesenchymal transition, angiogenesis, cancer stem cells and drug resistance. Furthermore, we provide a future perspective for OIP5-AS1 research. We conclude that targeting OIP5-AS1 might be a promising cancer therapy approach. |
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