Serological characterization of previously unknown H-2 molecules identified in the products of theK
d
andD
k
region |
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Authors: | Dagmar Iványi Peter Démant |
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Institution: | (1) Division of Genetics, Antoni van Leeuwenhoekhuis, The Netherlands Cancer Institute, Amsterdam, The Netherlands |
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Abstract: | The molecular relationship between H-2 private and some public specificities was studied in C3H.OH (H-2
02
) mice using surface-antigen re-distribution methods. Besides the Kd- and Dk-region antigens, which can be capped by antisera against the private and public specificities characteristic for a given allele, a previously unknown type of molecule was found in the products of both theK
d
andD
k
regions. These can be capped by the respective anti-private serum but not by antisera against some public specificities. The two Kd-region molecules are provisionally named H-2K1d and H-2K2d. We detected them onH-2
02
(K
d
,I
d
,S
d
,D
k
) and also onH-2
dx
(K
d
,I
f
,S
f
,D
dx
) T lymphocytes. Similarly, the two types of molecules detected on the products of theD
k
region are provisionally named H-2D1k and H-2D2k. The serological characteristics of these molecules are described. When compared with the products of theD
d
region, in which we previously described three different molecules (H-2Dd, H-2Md, and H-2Ld), the mutual relationship between H-2K1d and H-2K2d as well as between H-2D1k and H-2D2k appears to be similar to that between H-2Dd and H-2Md. In the absence of relevant recombinants or informative biochemical data, it is, however, difficult to establish homology between molecules produced by differentK- andD-region alleles. |
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Keywords: | |
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