Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces |
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| Authors: | Hanka Venselaar Tim AH te Beek Remko KP Kuipers Maarten L Hekkelman Gert Vriend |
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| Institution: | 1.CMBI, NCMLS,Radboud University Nijmegen Medical Centre,Nijmegen,Netherlands;2.NBIC,Netherlands Bioinformatics Centre,Nijmegen,The Netherlands;3.Laboratory of Systems and Synthetic Biology,Wageningen University,Wageningen,The Netherlands;4.BioProdict,Wageningen,The Netherlands |
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| Abstract: | Background Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects
on the protein's 3D structure provides insight into the protein's mechanism, can aid the design of further experiments, and
eventually can lead to the development of new medicines and diagnostic tools. |
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