Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data |
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Authors: | Regev Schweiger Michal Linial |
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Institution: | (1) School of Computer Science and Engineering, Hebrew University of Jerusalem, 91904, Israel;(2) Department of Biological Chemistry, Institute of Life Sciences, Sudarsky Center for Computational Biology, Hebrew University of Jerusalem, 91904, Israel |
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Abstract: | Background Phosphorylation is the most prevalent post-translational modification on eukaryotic proteins. Multisite phosphorylation enables
a specific combination of phosphosites to determine the speed, specificity and duration of biological response. Until recent
years, the lack of high quality data limited the possibility for analyzing the properties of phosphorylation at the proteome
scale and in the context of a wide range of conditions. Thanks to advances of mass spectrometry technologies, thousands of
phosphosites from in-vivo experiments were identified and archived in the public domain. Such resource is appropriate to derive
an unbiased view on the phosphosites properties in eukaryotes and on their functional relevance. |
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Keywords: | |
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