Existence and function of a receptor for immunoglobulin A on human eosinophils |
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Authors: | M Capron M Tomassini E Van der Vorst J P Kusnierz J P Papin A Capron |
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Affiliation: | Unité Mixte I.N.S.E.R.M., U 167-C.N.R.S., Institut Pasteur, Lille. |
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Abstract: | The existence of receptors for immunoglobulin A on human eosinophils is demonstrated by flow cytofluorometry. Between 5 and 60% of eosinophils purified from peripheral blood of hypereosinophilic patients are able to bind monomeric serum IgA. The addition of antihuman IgA antibodies to surface IgA-bearing eosinophils induces the exocytosis of peroxidase contained in the granules suggesting a cell activation due to IgA receptors. The inhibition of antiparasitic cytotoxicity by eosinophils preincubated with IgA under a polymeric form only, indicates the low affinity of IgA receptors as well as their participation in the effector function of eosinophils. |
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