鲜猴头菌口服液益智保健功效初步研究

初步评估了鲜猴头菌口服液的益智保健功效以及对糖尿病及其相关症状的改善作用。在研究中，首先采用急性毒性实验检测鲜猴头菌口服液饮用的安全性；然后，采取小鼠跳台和避暗实验以及迟发型变态反应初步分析了鲜猴头菌口服液对正常小鼠的学习和记忆能力以及对由Cy诱导的免疫抑制小鼠的细胞免疫应答能力的影响；同时，又以STZ诱导的糖尿病大鼠作为模型，测定了鲜猴头菌口服液对糖尿病典型症状的改善作用。结果显示，鲜猴头菌口服液的LD50＞27.2mL/kg；在跳台和避暗2个实验中，与空白对照组相比较，猴头低、中、高3个剂量组小鼠的潜伏期明显缩短，且5min错误次数明显减少；在迟发型变态反应中，与阴性对照组相比较，猴头组小鼠的左后足趾肿胀度极显著增强；此外，鲜猴头菌口服液还对由STZ诱导的糖尿病大鼠的精神状态和体重均有改善作用，而与正常组相比较，口服液对糖尿病大鼠的血常规指标影响不明显。这表明，鲜猴头菌口服液为安全物质，它能显著的提高小鼠的记忆和学习能力，能极显著的提高免疫抑制小鼠的细胞免疫应答水平，还能对由糖尿病引起的体重下降有改善作用，同时不会引起副作用。

A preliminary study of fresh Hericium erinaceus oral liquid on health-care function and promotion of learning and memory

The study was designed to investigate the toxicity of fresh Hericium erinaceus oral liquid and its treatment effects on learning and memory, DTH reaction in a mouse model of immunosuppression, and STZ-induced diabetes in a rat model. The results showed that the LD50 of fresh Hericium erinaceus oral liquid is higher than the dose of 27.2mL/kg. In the stay-down and stay-through assays, the time of latency and the number of errors made in the 5 minutes in the oral liquid-treated group was apparently less than those of the other groups. In the delayed type hypersensitivity (DTH) reaction, the swell of left back toes in the oral liquid-treated immunosuppressed mice was significantly bigger than that in the non-treatment immunosuppressed mice. In addition, the body weight of STZ-induced diabetic rats in the oral liquid-treated group was significantly improved in comparison with that before taking the oral liquid, and the haematological traits of diabetic rats in the oral liquid-treated group were not obvious as compared with those in the normal control group. The conclusion is that fresh Hericium erinaceus oral liquid is no toxicity, and it can significantly improve the ability of learning and memory, and strengthen the responses of the cellular immunity in mice. Besides, it can protect rats against STZ-induced diabetes.