Unconventional myosins at the crossroad of signal transduction and cytoskeleton remodeling |
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Authors: | Thierry Soldati Eva C Schwarz and Heidrun Geissler |
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Institution: | (1) Department of Molecular Cell Research, Max-Planck-Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Federal Republic of Germany |
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Abstract: | Summary The cytoplasm of eukaryotic cells is a complex milieu and unraveling how its unique cytoarchitecture is achieved and maintained
is a central theme in modern cell biology. The actin cytoskeleton is essential for the maintenance of cell shape and locomotion,
and also provides tracks for active intracellular transport. Myosins, the actin-dependent motor proteins form a superfamily
of at least 15 structural classes and have been identified in a wide variety of organisms, making the presence of actin and
myosins a hallmark feature of eukaryotes. Direct connections of myosins to a variety of cellular tasks are now emerging, such
as in cytokinesis, phagocytosis, endocytosis, polarized secretion and exocytosis, axonal transport. Recent studies reveal
that myosins also play an essential role in many aspects of signal transduction and neurosensation. |
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Keywords: | Dictyostelium discoideum Myosin Signal transduction Cytoskeleton |
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