Variability of sensitivity of lymphocytes from healthy donors to antiproliferative effect of dexamethasone and HLA antigens

A positive correlation between the level of lymphocyte PHA-stimulation and the degree of stimulation inhibition by dexamethasone has been established. Using regression analysis methods, healthy volunteers were divided into three groups: sensitive, intermediate and resistant. The frequency of HLA-B7, B12 and DR2 antigens was increased in the latter group.