The Endothelin ETA Receptor Exists in the Caudal Solitary Tract Nucleus of the Rat Brain |
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| Authors: | Shigeki Shibata Masami Niwa Akihiko Himeno Nanette G Gana Kazuto Shigematsu Masanori Matsumoto Kimihiro Yamashita Kohji Sumikawa Kohtaro Taniyama |
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| Institution: | (1) Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852, Japan;(2) Department of Pharmacology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852, Japan;(3) Department of Pharmacology, College of Medicine, University of the Philippines, Manila, Republic of Philippines;(4) Department of Pathology, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852, Japan |
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| Abstract: | 1. The receptor autoradiographic method done on the rat lower brain stem and cerebellum plus 125I-endothelin-1, BQ-123, an antagonist for the endothelin ETA receptor, and sarafotoxin S6c, an agonist for the ETB receptor, revealed minute amounts of the ETA receptor coexisting with the ETB receptor in the caudal solitary tract nucleus of the rat lower brain stem.2. The ETB receptor is present predominantly in other parts of the lower brain stem.3. Knowledge of the heterogeneous distribution of the central endothelin receptor subtypes aids in understanding the neurophysiology of endothelins. |
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| Keywords: | endothelin ETA receptor ETB receptor solitary tract nucleus rat lower brain stem BQ-123 sarafotoxin S6c |
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