青春双歧杆菌对2型糖尿病模型大鼠肠道菌群和脂质代谢的影响

目的通过观察青春双歧杆菌对2型糖尿病模型大鼠肠道菌群的变化,和血清中总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、超氧化物歧化酶（SOD）和丙二醛（MDA）的水平,探讨青春双歧杆菌对2型糖尿病模型大鼠肠道功能和脂质代谢的影响。方法采用青春双歧杆菌灌胃2型糖尿病模型大鼠,取粪便检查正常菌群,取血和脏器检测TC、TG、HDL-C、SOD和MDA含量。结果青春双歧杆菌导致肠道内双歧杆菌、乳杆菌的数量增加,而肠杆菌、肠球菌数量下降;TC、TG和MDA水平下降,而HDL-C和SOD水平升高。结论青春双歧杆菌具有改善2型糖尿病模型大鼠肠道功能和降血脂作用,与二甲双胍联合应用效果更佳。

Influence of Bifidobacterium adolescentis on intestinal flora and lipid metabolism in type 2 diabetes mellitus rats

Objective To observe the change of intestinal flora caused by Bifidobacterium adolescentis and the levels of total cholesterol, Triglyceride, high density lipoprotein, superoxide dismutase and malondialdehyde in type 2 diabetes mellitus rats,and explore the influence of Bifidobacterium adolescentis on intestinal flora and lipid metabolism in type 2 diabetes mellitus rats. Method The levels of normal flora, total cholesterol, Triglyceride, high density lipoprotein,superoxide dismutase and malondialdehyde were examined after gavaging type 2 diabetes mellitus rats by Bifidobacterium adolescentis. Result Bifidobacterium adolescentis had caused the number of bifidobacterium and lactis to increase while that of Enter-obacter and Enterococcus to decrease;The levels of total cholesterol, Triglyceride and malondialdehyde were reduced while those of high density lipoprotein and superoxide dismutase were improved. Conclusion Bifidobacterium adolescentis has the effect of improving intestinal function and lowering serum lipids in type 2 diabetes mellitus rats,the effect of which can be improved when combined with metformin.