A serine, threonine and proline-rich region near the carboxyl-terminus of a rat intestinal mucin peptide. |
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Authors: | L J Huan G Xu G Forstner J Forstner |
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Affiliation: | Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. |
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Abstract: | Further sequencing of a cDNA encoding the C-terminal region of a rat intestinal mucin peptide reveals a region corresponding to 258 amino acids enriched in serine, threonine and proline, but no typical mucin-like tandem repeat structures. Between this region and a previously described stretch of 4.5 degenerate S,T,P-rich tandem repeats, there is a 42 amino acid cysteine-rich segment. The discontinuity of cysteine-rich and S,T,P-rich areas near the C-terminus has not been observed in other mammalian mucin structures reported to date. |
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